Endocrine Abstracts

The incidence of childhood thyrotoxicosis in the UK and Ireland is unknown. The commonest cause worldwide is Graves’ disease (60–90% of cases), with reported incidences varying from 0.79 (Denmark) to 6.5 (Hong Kong) per 100,000 pop./yr. Mean age at diagnosis is reported as 11.3 years with a F:M ratio of 5.5:1. Some countries have recently reported an increasing incidence.To ascertain the UK and Ireland incidence of childhood thyrotoxicosis and ...

Exaggerated adrenarche (EA) has been linked with low birth weight (LBW) and future development of hyperinsulinaemia and ovarian hyperandrogenism. The Scottish Paediatric Endocrine Group conducted a 3-year prospective study (2004–07) to examine the auxology, insulin status and steroid biochemistry of patients with a clinical diagnosis of EA. Fifty-one patients (43F:8M) were recruited. A 10 ml blood sample (fasted) was taken for biochemical analysis. Pubertal status was ass...